The circuit starts in Arusha and includes, from east to west: Arusha National Park at the foot of Mount Meru, Tarangire National Park 110km southwest of the town of Arusha, Manyara Ranch between Tarangire National Park and Lake Manyara National Park, Lake Manyara National Park at the bottom of the Gregory Rift, the Ngorongoro Conservation Area (which includes the Ngorongoro caldera, the Empakaai Crater and the southern Serengeti plains of Lake Ndutu), and the Serengeti National Park that stretches north to the Tanzania/Kenya border.

Within a relatively compact geographical area, safari goers will have access to a multitude of other iconic parks and major tourist attractions, including Olduvai Gorge, Lake Natron, Ol Doinyo Lengai volcano and Mount Meru.